Imposes comprehensive requirements on covered entities regarding electronic health records (EHRs) in Texas. Requires EHRs to be physically stored in the United States, limits access to authorized personnel, and mandates reasonable safeguards for confidentiality, integrity, and availability. Requires EHRs to include fields for biological sex as observed at birth and sexual development disorders, and mandates that any algorithm or decision assistance tool in an EHR use biological sex data. Permits health care practitioners to use AI for diagnostic purposes if they review AI-generated records consistent with Texas Medical Board standards and disclose AI use to patients. Prohibits storing credit score or voter registration data in EHRs and requires parental access to minors' records. Enforced by the HHSC, regulatory agencies, and the attorney general through investigations, disciplinary actions, injunctive relief, and civil penalties up to $250,000.